Increase in solubility, dissolution rate and bioavailability of new chemical entity (Drugs) is a very tough and essential task in drug development process, approximately 40% of the new chemical entities which are being discovered are poorly water soluble or practically insoluble drugs. Solubility of any therapeutically active substance in aqueous media is a key property as it governs dissolution, absorption and thus the in vivo efficacy. Drugs which are administered orally get completely absorb only when they show fair solubility in gastric medium and such drugs shows good bioavailability. The solubility and dissolution properties of drugs play an important role in the process of formulation development. Problem of solubility is a major challenge for formulation scientist which can be solved by different technological approaches during the pharmaceutical product development work. The present review deals in detail about the different nanotechnology based techniques used to improvement of the solubility and dissolution rate of poorly water soluble drugs and application of nanoparticle and there dosage form.
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